Next generation biofilm - the "Rose of Jericho" of biotechnology

(German title: Next Generation Biofilm - die "Rose von Jericho" der Biotechnologie)

The project relates to the objectives of the National Research Strategy BioEconomy 2030 in the field of action "Industrial utilisation of renewable raw materials". Food production and the production of energy and recyclable materials are increasingly competing with each other (plate-or-tank problem). One of the major challenges for the future is therefore to sustainably meet the growing demand for food, energy and recyclable materials while minimising the consumption of agricultural land, energy and water resources. The sustainable production of proteins (proteins), lipids (fats) and carbohydrates (sugars & polysaccharides) by cyanobacteria, microalgae or plants is of central importance here.

Cyanobacteria, for example, harbour an enormous pool of renewable biopharmaceuticals and fine chemicals. However, this potential is hardly being utilised as current production processes are too energy and resource intensive. In contrast, this project is the first to use photosynthesising, desiccation-tolerant biofilms (terrestrial cyanobacteria) for the steam-controlled production of bacterial polysaccharides and dyes. A resource- and energy-efficient process technology is used here, which is realised by means of a new generation of emersed photobioreactors (ePBR).

Publications and conference papers

  • J. Stiefelmaier, D. Strieth, S. Di Nonno, N. Erdmann, K. Muffler, R. Ulber; Characterization of terrestrial phototrophic biofilms of cyanobacterial species; Algal Research (2020) https://doi.org/10.1016/j.algal.2020.101996
  • K. Scherer, J. Stiefelmaier, D. Strieth, M. Wahl, R. Ulber; Development of a lightweight multi-skin sheet photobioreactor for future cultivation of phototrophic biofilms on facades; Journal of Biotechnology (2020) https://doi.org/10.1016/j.jbiotec.2020.06.004
  • D. Strieth, J. Stiefelmaier, B. Wrabl, J. Schwing, A. Schmeckebier, S. Di Nonno, K. Muffler, R. Ulber Roland; A new strategy for a combined isolation of EPS and pigments from cyanobacteria; Journal of Applied Phycology (2020) https://link.springer.com/content/pdf/10.1007/s10811-020-02063-x.pdf
  • J. Stiefelmaier, B. Ledermann, M. Sorg, D. Geib, R. Ulber, N. Frankenberg-Dinkel; Pink bacteria—Production of the pink chromophore phycoerythrobilin with Escherichia coli; Journal of Biotechnology 274 (2018) 47-53; https://doi.org/10.1016/j.jbiotec.2018.03.006
  • D. Strieth, J. Schwing, S. Kuhne, M. Lakatos, K. Muffler, R. Ulber; A semi-continuous process based on an ePBR for the production of EPS using Trichocoleus sociatus; J. of Biotechn. 256 (2017) 6-12, http://dx.doi.org/doi:10.1016/j.jbiotec.2017.06.1205
  • D. Strieth, R. Ulber, K. Muffler; Application of phototrophic biofilms: From fundamentals to Processes; Bioprocess and Biosystems Engineering 41 (2018) 295–312; https://doi.org/10.1007/s00449-017-1870-3
  • D. Strieth, J. Stiefelmaier, R. Ulber; Terrestrial cyanobacteria – a potential source for new bioactive compounds and natural dye; ProcessNet-Jahrestagung und 32. DECHEMA-Jahrestagung der Biotechnologen (2016) Aachen
  • D. Strieth, R. Ulber; Production of bioactive substances: New reactor systems for the cultivation of cyanobacteria; ChemBioMed V: Molecular Switches in Disease & Development (2015) Mainz