Das Lehrgebiet BioVT ist Co-Autor bei dem Review "Structural tailoring of fucoidans backbone for maximizing their benefits: Enzymatic, chemical, and physical strategies" in dem Journal of Applied Phycology.
Fucoidans are recognized as heterogenous, high molecular weights, sulfated, and bioactive polysaccharides derived from brown seaweeds. Nevertheless, their bioactivites are variable and determined potentially with regard to various chemical properties, including molecular masses, and sulfation pattern and degree,. For instance, most anticoagulant and immunomodulatory activities have been associated with high and low molecular weight fucoidans, respectively. Moreover, pharmacokinetic parameters and pharmaceutical formulation are affected by such properties, where high molecular weights of fucoidans have hindered oral absorption and consequently distribution to various body organs. Hence, different methods have been developed to modify the native fucoidans in order to produce more bioactive and efficiently formulated products. The current article highlighted the present various enzymatic (e.g., fucoidanase and fucoidan sulfatase), chemical, and other used strategies for structural modifications of native fucoidans accompanied with varied bioactivities. Hence, this review may help tailoring of new fucoidan derivatives for targeted homogenous production of fucoidans in medical and pharmaceutical fields.