Lehrstuhl für Mechanische Verfahrenstechnik (MVT)

Particle formulation

For various products, e.g. in the pharmaceutical, chemical and food industries, the formulation of solid particles with different substances is an important production step. At the Institute of Particle Process Engineering numerical simulation tools are used to develop new apparatus, to gain further information about particle motion and to optimize special particle processes, e.g. spheronization of cylindrical particles or coating of particles.
The current project in this area is called "Analysis of fluidization and shear conditions in rotor fluid beds under dry and wet conditions". The influence of fluid and particle shape on particle dynamics in a dense, sheared gas-solid flow is investigated. Granulation and coating are modeled with a CFD-DEM approach. Using the example of a rotor fluidized bed, detailed experimental investigations of the particle dynamics are carried out using a novel MPT measuring technique under dry and wet conditions (spraying liquids).

Research Areas

Research Projects

Completed Research Projects

Recent Publications

Vafaeezadeh, M., Weber, K., Demchenko, A., Lösch, P., Breuninger, P., Lösch, A., Kopnarski, M., Antonyuk, S., Kleist, W., Thiel, W. R.: Janus bifunctional periodic mesoporous organosilica, Chemical Communications 58 (2022) 112-115, https://doi.org/10.1039/D1CC06086D 

Grohn, P., Oesau, T., Heinrich, S., Antonyuk, S.: Investigation of the influence of wetting on the particle dynamics in a fluidized bed rotor granulator by MPT measurements and CFD-DEM simulations, Powder Technology 408 (2022) 117736 https://doi.org/10.1016/j.powtec.2022.117736

Grohn, P., Oesau, T., Heinrich, S., Antonyuk, S.: Investigation of the influence of impact velocity and liquid bridge volume on the maximum liquid bridge length, Advanced Powder Technology 33 (2022) 6, 103630, https://doi.org/10.1016/j.apt.2022.103630

Weis, D.: Beschreibung des Sphäronisationsprozesses von pharmazeutischen Pellets mittels numerischer Methoden. Dissertation, Schriftenreihe des Lehrstuhls für Mechanische Verfahrenstechnik der TU Kaiserslautern, (2021) Band 24, ISBN 978-3-95974-144-6

T. Oesau, P. Grohn, S. Pietsch-Braune, S. Antonyuk, S. Heinrich (2021): Novel approach for measurement of restitution coefficient by magnetic particle tracking, Advanced Powder Technology, https://doi.org/10.1016/j.apt.2021.11.014

Evers, M., Weis, D., Antonyuk, S., Thommes, M.: Particle movement in the spheronizer – Experimental investigations with respect to the toroidal and poloidal direction, Powder Technology 404 (2022) 117452, https://doi.org/10.1016/j.powtec.2022.117452

Vafaeezadeh, M., Weber, K., Demchenko, A., Lösch, P., Breuninger, P., Lösch, A., Kopnarski, M., Antonyuk, S., Kleist, W., Thiel, W. R.: Janus bifunctional periodic mesoporous organosilica, Chemical Communications 58 (2022) 112-115, https://doi.org/10.1039/D1CC06086D

Dominik Weis, Philipp Grohn, Maria Evers, Markus Thommes, Edwin García, Sergiy Antonyuk (2020): “Implementation of formation mechanisms in DEM simulation of the spheronization process of pharmaceutical pellets”, Powder Technology. https://doi.org/10.1016/j.powtec.2020.09.013

Philipp Grohn, Marius Lawall, Tobias Oesau, Stefan Heinrich, Sergiy Antonyuk (2020): “CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator”, Processes 8 (9), S. 1090. https://doi.org/10.3390/pr8091090

Philipp Grohn, Dominik Weis, Markus Thommes, Stefan Heinrich, Sergiy Antonyuk (2020): “Contact behavior of MCC pellets depending on their water content”, Chemical Engineering & Technology 2020, https://doi.org/10.1002/ceat.201900517

Weis, D.; Krull, F.; Mathy, J.; Evers, M.; Thommes, M.; Antonyuk, S.: A contact model for the deformation behaviour of pharmaceutical pellets under cyclic loading, Advanced Powder Technology (2019), In Press, https://doi.org/10.1016/j.apt.2019.07.026

Weis, D.; Niesing, M.; Thommes, M.; Antonyuk, S.: DEM simulations of the mixing behavior in a spheronization process, Chemical Engineering Science 192 (2018), 803-815, https://doi.org/10.1016/j.ces.2018.07.057

Breuninger, P.; Weis, D.; Behrendt, I.; Grohn, P.; Krull, F.; Antonyuk, S.: CFD-DEM simulation of fine particles in a spouted bed apparatus with a Wurster tube, Particuology (2018), https://doi.org/10.1016/j.partic.2018.03.015

Weis, D.; Niesing, M.; Thommes, M.; Antonyuk, S.: Partikelkinematik in der Sphäronisation pharmazeutischer Pellets, Chemie Ingenieur Technik (2017),https://doi.org/10.1002/cite.201600154

Vafaeezadeh, M., Wilhelm, C., Breuninger, P., Ernst, S., Antonyuk, S. and W. R. Thiel: A Janus-type heterogeneous phase transfer catalyst for adipic acid synthesis, ChemCatChem (2020) https://doi.org/10.1002/cctc.202000140

M. Vafaeezadeh, P. Breuninger, P. Lösch, C. Wilhelm, S. Ernst, S. Antonyuk, W. Thiel: Janus Interphase Organic‐Inorganic Hybrid Materials: Novel Water‐Friendly Heterogeneous Catalysts, ChemCatChem (2019), https://doi.org/10.1002/cctc.201900147

Laboratory Equipment

Uniaxial compression/tension tester in MicroCT

Insitu measurement of deformation and breakage behaviour (force rage 1-500 N) in the microcomputed tomography (minimum voxel size 500 nm)

100 kHz Acoustic Levitator

Investigation of the evaporation of micro droplets at different airflows and air humidities

Spouted bed apparatus

In house developed apparatus for coating of very finde (Geldart C) particles

SEM

Optical analysis of the particle size, form and roughness

Triboindenter

Meaurements of the particle defor-mation behaviour depending on the temperature, particle roughness

Texture Analyser

Meaurements of the particle deformation behaviour depending on the temperature and air humidity and meaurements of particle friction coefficients

High speed cameras

Measurement of dynamic impact of particle / droplet

Simulation Tools

ANSYS CFX, ANSYS Fluent 

OpenFOAM 

LIGGGHTS / CFDEMcoupling 

EDEM solutions